a Record control number 000316913800008

a ISSN 0885-6222

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL100.3

b Item number .L48 2013

a Personal name Doganavsargil-Baysal, Ozge.

a Title Levels of TNF-, soluble TNF receptors (sTNFR1, sTNFR2), and cognition in bipolar disorder.

h Medium Electronic Document

c Statement of responsibility, etc Ozge Doganavsargil-Baysal, Buket Cinemre, Umut Mert Aksoy, Halide Akbas, Ozmen Metin, Cıgıl Fettahoglu, Zehra Gokmen and Fatih Davran.

b Name of publisher, distributor, etc Wiley-Blackwell,

c Date of publication, distribution, etc 2013.

a Summary, etc Objective Tumor necrosis factor-alpha (TNF-) may play an important role in bipolar disorder (BD) pathogenesis. There is only one study about a relationship between TNF- levels and cognitive impairments in BD. The aim of the present study was to see whether TNF-, soluble P55 TNF receptor (sTNFR1), and soluble P75 TNF receptor (sTNFR2) levels in BD patients are different from controls and to investigate the relationships between the levels of TNF-, sTNFR1, and sTNFR2 and the cognitive functions in euthymic BD patients and controls. Methods We assessed 54 BD type I patients and 18 controls by using a battery of neuropsychological tests. Serum TNF- levels were measured using a commercially available enzyme-linked immunosorbent assay, whereas serum sTNFR1 and sTNFR2 levels were measured using a commercially enzyme-amplified sensitivity immunoassay kit. Results We found that levels of sTNFR1 and sTNFR2 in BD patients were different from controls. No difference was detected between the BD group and the control group for levels of TNF-. TNF- level was found to have a negative correlation with the delayed recall in RAVLT. Conclusions High levels of sTNFR1 and sTNFR2 in euthymic patients showed that it may support that proinflammatory process continues in euthymic period. This is the first study which showed increased sTNFR2 levels in euthymic period, which could be interpreted as a compensatory mechanism and again the first which deals with verbal memory. Copyright (c) 2013 John Wiley & Sons, Ltd.

a Topical term or geographic name as entry element Clinical Neurology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Pharmacology & Pharmacy

a Topical term or geographic name as entry element Bipolar disorder.

g Relationship information MAR 2013, Vol 28 Issue 2, p160-167

t Title Human Psychopharmacology

t Title Clinical And Experimental

x International Standard Serial Number 08856222

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1002/hup.2301